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- Title
Case Report: Rubella Virus-Induced Cutaneous Granulomas in Two Pediatric Patients With DNA Double Strand Breakage Repair Disorders - Outcome After Hematopoietic Stem Cell Transplantation.
- Authors
Baumann, Ulrich; Schulte, Johannes H.; Groß, Jonathan P.; Beier, Rita; Ludwig, Marius; Wahn, Volker; Hofmann, Jörg; Maecker-Kolhoff, Britta; Sauer, Martin; Kaiser-Labusch, Petra; Karimian, Negin; Blume-Peytavi, Ulrike; Ghoreschi, Franziska; Ott, Hagen; Perelygina, Ludmila; Klemann, Christian; Blankenstein, Oliver; von Bernuth, Horst; Krüger, Renate
- Abstract
We report two patients with DNA repair disorders (Artemis deficiency, Ataxia telangiectasia) with destructive skin granulomas, presumably triggered by liveattenuated rubella vaccinations. Both patients showed reduced naïve T cells. Rapid resolution of skin lesions was observed following hematopoietic stem cell transplantation. However, the patient with AT died due to complications of severe hepatic veno-occlusive disease 6 month after HSCT. Dried blood spots obtained after birth were available from this patient and showed absent T-cell receptor excision circles (TRECs). Therefore, newborn screening may help to prevent patients with moderate T-cell deficiency from receiving live-attenuated rubella vaccine potentially causing granulomas.
- Subjects
HEPATIC veno-occlusive disease; HEMATOPOIETIC stem cell transplantation; CHILD patients; RUBELLA vaccines; ATAXIA telangiectasia; RUBELLA
- Publication
Frontiers in Immunology, 2022, Vol 13, p1
- ISSN
1664-3224
- Publication type
Case Study
- DOI
10.3389/fimmu.2022.886540