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- Title
Interaction of streptococcal plasminogen binding proteins with the host fibrinolytic system.
- Authors
Fulde, Marcus; Steinert, Michael; Bergmann, Simone
- Abstract
The ability to take advantage of plasminogen and its activated form plasmin is a common mechanism used by commensal as well as pathogenic bacteria in interaction with their respective host. Hence, a huge variety of plasminogen binding proteins and activation mechanisms exist. This review solely focuses on the genus Streptococcus and, in particular, on the so-called non-activating plasminogen binding proteins. Based on structural and functional differences, as well as on their mode of surface linkaging, three groups can be assigned: M-(like) proteins, surface displayed cytoplasmatic proteins with enzymatic activities ("moonlighting proteins") and other surface proteins. Here, the plasminogen binding sites and the interaction mechanisms are compared. Recent findings on the functional consequences of these interactions on tissue degradation and immune evasion are summarized.
- Subjects
STREPTOCOCCAL diseases; BACTERIAL proteins; PLASMINOGEN activators; CARRIER proteins; FIBRINOLYTIC agents; PATHOGENIC bacteria
- Publication
Frontiers in Cellular & Infection Microbiology, 2013, Vol 3, p1
- ISSN
2235-2988
- Publication type
Article
- DOI
10.3389/fcimb.2013.00085