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- Title
Nucleotide polymorphisms upstream of the X-chromosome opsin gene array tune L:M cone ratio.
- Abstract
In support of the long-held idea that cone ratio is genetically determined by variation linked to the X-chromosome opsin gene locus, the present study identified nucleotide differences in DNA segments containing regulatory regions of the L and M opsin genes that are associated with significant differences in the relative number of L versus M cones. Specific haplotypes (combinations of genetic differences) were identified that correlated with high versus low L:M cone ratio. These findings are consistent with the biological principle that DNA sequence variations affect binding affinities for protein components of complexes that influence the relative probability that an L versus M opsin gene will be silenced during development, and in turn, produce variation in the proportion of L to M cones.
- Subjects
NUCLEOTIDES; GENETIC polymorphisms; X chromosome; MATHEMATICAL transformations; DNA
- Publication
Visual Neuroscience, 2008, Vol 25, Issue 3, p265
- ISSN
0952-5238
- Publication type
Article
- DOI
10.1017/S0952523808080280