We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Retinal bipolar cell types differ in their inventory of ion channels.
- Authors
ELENA IVANOVA; FRANK MÜLLER
- Abstract
Bipolar cells were recorded in rat retinal slices to study the distribution of hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels. Patch-clamp whole cell measurements were combined with intracellular filling and recorded cells were morphologically identified. HCN channel isoforms HCN1-4 are differentially expressed in bipolar cells. Each bipolar cell type has a characteristic inventory of HCN channels. The combination of HCN channel currents and other voltage-gated currents can be used as a kind of “finger print” to electrophysiologically identify and classify bipolar cell types. Using this approach of combined electrophysiological and morphological classification we could identify a new ON-cone bipolar cell type.
- Publication
Visual Neuroscience, 2006, Vol 23, Issue 2, p143
- ISSN
0952-5238
- Publication type
Article
- DOI
10.1017/s0952523806232048