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- Title
Evaluation of the in vivo behaviour of gentamicin sulphate ocular mini-tablets in ponies.
- Authors
GASTHUYS, F.; POCKELÉ, K.; VERVAET, C.; WEYENBERG, W.; DE PRIJCK, K.; PILLE, F.; VLAMINCK, L.; NELIS, H.; REMON, J. P.
- Abstract
The in vivo behaviour of 5% gentamicin sulphate ocular mini-tablets (2-mm diameter, 6.525 mg weight) was compared with gentamicin eye drops in six ponies. Two mini-tablets were inserted on the bulbar conjunctiva of the right eye while a similar dose of gentamicin was administered via eye drops in the left eye. Irritation induced by the mini-tablets and the eye drops was evaluated using a visual analogue scale (0–10). Tears were sampled with ophthalmologic absorption triangles for 1 min for the determination of the concentration of gentamicin sulphate using a microbiological plate diffusion method. Irritation induced by the tablets was minor and clinically acceptable (overall median score of 1.7 ± 1.4). Eye drops induced a sharp increase in gentamicin sulphate concentration (364.4 μg/mL after 5 min) followed by a fast decline (10.8 μg/mL after 60 min). The increase in concentration induced by the ocular mini-tablets was less pronounced (up to 56.2 μg/mL after 30 min) and followed by a gradual decrease; the concentration remained above 15 μg/mL for 8 h. Ocular 5% gentamicin sulphate mini-tablets are clinically well-tolerated in ponies, assuring a constant concentration in the tears for at least 8 h.
- Subjects
GENTAMICIN; PONIES; OCULAR pharmacology; ANTIBACTERIAL agents; PHARMACOLOGY
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 2007, Vol 30, Issue 5, p470
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1111/j.1365-2885.2007.00890.x