We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Functional gastrointestinal disorders in 35 447 adults and their association with body mass index.
- Authors
Le Pluart, D.; Sabaté, J.‐M.; Bouchoucha, M.; Hercberg, S.; Benamouzig, R.; Julia, C.
- Abstract
Background Functional gastrointestinal disorders' ( FGIDs) associations with body mass index ( BMI) have not been thoroughly investigated in the general population. Aim To investigate the overlap between functional dyspepsia ( FDy), irritable bowel syndrome ( IBS), functional constipation ( FC) and functional diarrhoea ( FDh) and the relationship between BMI and those diagnoses in a large French adult population. Methods Subjects participating in the Nutrinet-Santé cohort study completed a questionnaire based on Rome III criteria. Anthropometrics, socio-demographical and lifestyle data were collected via self-administered questionnaires. Associations between BMI and FGIDs were investigated with multivariate logistic regression. Results A total of 35 447 subjects were included in the analysis. Among subjects with FGIDs, 10.4% presented more than one disorder. [ FDy coexisted with IBS (23.6%) and FC (15.1%)]. Associations between BMI and FDy differed according to sex. In females, higher odds were observed for underweight and obesity subgroups ( OR = 1.26 (95% CI: 0.99-1.59), OR = 1.35 (1.08-1.69), OR = 1.20 (0.81-1.77), OR = 1.47 (0.89-2.42) for underweight, class I, II and III obesity respectively compared with normal BMI), forming a U-shaped relationship confirmed with nonlinear model ( P < 0.001). In females, FDh was associated with BMI [ OR = 1.05 (1.03-1.07), P < 0.001]. In males, a negative association between BMI and IBS was observed [ OR = 0.97 (0.94-0.99), P=0.04]. Other associations were not significant. Conclusions Our study showed an important overlap in FGIDs, supporting the contention of common pathophysiological mechanisms. Relationships between BMI and FGIDs appeared to be sex-dependent. Interaction by sex in the association between BMI and FGIDs should therefore be further explored.
- Subjects
GASTROINTESTINAL diseases; BODY mass index; INDIGESTION; CONSTIPATION; ANTHROPOMETRY; DIARRHEA
- Publication
Alimentary Pharmacology & Therapeutics, 2015, Vol 41, Issue 8, p758
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/apt.13143