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- Title
Prior chemoradiotherapy is associated with a higher life-threatening complication rate after palliative insertion of metal stents in patients with oesophageal cancer.
- Authors
LECLEIRE, S.; DI FIORE, F.; BEN‐SOUSSAN, E.; ANTONIETTI, M.; HELLOT, M.‐F.; PAILLOT, B.; LEREBOURS, E.; DUCROTTÉ, P.; MICHEL, P.
- Abstract
Background Self-expanding metal stents are used routinely to palliate dysphagia due to oesophageal cancer. Study aim To compare the frequency of life-threatening complications after self-expanding metal stent insertion, depending on whether patients received prior chemoradiotherapy or no treatment. Patients and methods During 7 years, 116 consecutive patients were treated at a single centre in a palliative intent by insertion of self-expanding metal stent for dysphagia due to an oesophageal cancer. Patients were retrospectively separated into two groups: patients with chemoradiotherapy before self-expanding metal stent insertion (group 1, n = 56) and patients with no treatment before or after self-expanding metal stent insertion (group 2, n = 60). Life-threatening complications were compared and predictive risk factors of postprocedure complications were identified. Results Median dysphagia was significantly improved during the first month (grade 3 to grade 1 in the two groups). Early and late major complications occurred more frequently in group 1 (23.2% vs. 3.3%; P < 0.002 and 21.6% vs. 5.1%; P < 0.02 respectively). Prior chemoradiotherapy was the only independent predictive factor of postprocedure major complications, with an odds ratio of 5.59 (CI 95% 1.7–18.1). Conclusions Life-threatening complications after palliative self-expanding metal stent placement seem to occur more frequently in patients with prior chemoradiotherapy. Prevention of these severe complications should be considered before stenting.
- Subjects
PALLIATIVE treatment; CANCER patients; DEGLUTITION disorders; CANCER; MEDICINE
- Publication
Alimentary Pharmacology & Therapeutics, 2006, Vol 23, Issue 12, p1693
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2006.02946.x