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- Title
No association between Y chromosomal haplogroups and severe acne in the Han Chinese population.
- Authors
Mei-Hua Guo; Wen-Juan Wu; Long Fan; Min-Sheng Peng; Jian-Kang Yang; Wen Zhang; Fei Hao; Hong-Fu Xie; Lei-Hong Xiang; Min Zheng; Yan-Ni Guo; Qing-Hua Song; Cai-Xia Tu; Hua Zhong; Wen-Ge Fan; Yue-Jun Shi; Ping Cao; Lian-Yuan Feng; Meng Na; Qin Pang
- Abstract
Severe acne presents sexual dimorphism in its incidence in Chinese population. It is more prevalent in males. To assess the possible Y chromosomal contribution to severe acne risk in Han Chinese males, we analyzed 2041 Y chromosomal SNPs (Y-SNPs) in 725 severe acne cases and 651 controls retrieved from our recent genome-wide association study data. After data filtering, we assigned 585 cases and 494 controls into 12 Y chromosomal haplogroups based on 307 high-confidence Y-SNPs. No statistically significant difference in the distribution of Y chromosomal haplogroup frequencies was observed between the case and control groups. Our results showed a lack of association between the incidence of severe acne and the different Y chromosomal haplogroup in the Han Chinese population.
- Subjects
Y chromosome; ACNE; CHINESE people; SEXUAL dimorphism; DISEASE incidence; SINGLE nucleotide polymorphisms; DISEASES
- Publication
Journal of Human Genetics, 2014, Vol 59, Issue 8, p475
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1038/jhg.2014.53