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- Title
PATTERNS OF CORTICAL ACTIVATION FOLLOWING MOTOR TASKS AND PSYCHOLOGICAL-INDUCING MOVIE CUES IN HEROIN USERS: AN fMRI STUDY.
- Authors
YAN-LING JIANG; WEI TIAN; GANG LU; RUDD, JOHN A.; LAI, K. F.; YEUNG, L. Y.; WAI, MARIA S. M.; YUAN YUAN LI; MING LONG HUANG; YEW, DAVID T.
- Abstract
Objective: Drug abuse and addiction are worldwide health problems. However, few studies have used fMRI to investigate the effect of chronic heroin use on brain activation. This is a study along this line. Method: fMRI positive sites in the brain were recorded during different motor and sensory activities. Results: Following motor activities, heroin users had more sites globally activated in the brain than in normal volunteers, with ex-heroin users being least reactive. Conversely, a "heroin puffing" movie produced more activation in ongoing-heroin and ex-heroin users than in the normal individuals, whereas a movie with explicit sexual content was less stimulatory in both groups of heroin users compared to normal individuals. Conclusions: These significant findings relative to the function of specific brain nuclei are discussed.
- Subjects
BRAIN; RADIOGRAPHY; BRAIN physiology; CEREBRAL cortex; MAGNETIC resonance imaging; HEROIN; MOTOR ability; NARCOTICS; RESEARCH funding; SUBSTANCE abuse; SURVEYS
- Publication
International Journal of Psychiatry in Medicine, 2014, Vol 47, Issue 1, p25
- ISSN
0091-2174
- Publication type
Article
- DOI
10.2190/PM.47.1.c