We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Lack of p19<sup>INK4d</sup> in human testicular germ-cell tumours contrasts with high expression during normal spermatogenesis.
- Authors
Bartkova, Jirina; Thullberg, Minna; Meyts, Ewa Rajpert-De; Skakkebæk, Niels E; Bartek, Jiri
- Abstract
p19INK4d, a member of the INK4 family of cyclin-dependent kinase inhibitors, negatively regulates the proto-oncogenic cyclin D/CDK4(6) complexes whose ability to phosphorylate the retinoblastoma tumour suppressor (RB) promotes G1/S transition. In contrast to the related p16INK4a tumour suppressor, expression patterns of 19INK4d in human tissues and tumours remain unknown. As the RB pathway is commonly targeted in cancer, and mouse models suggest a role for p19INK4d in spermatogenesis, we examined the abundance and localization of p19INK4d in the human testis, both during normal development and at various stages of germ-cell tumour pathogenesis. Our data show that the p19INK4d protein is abundant in spermatocytes of normal human adult testes, whereas virtually no p19INK4d is detectable in testicular cancer, including the preinvasive carcinoma in situ stage. Together with the lack of p19INK4d in human foetal germ cells, these results support the concept of foetal origin of the testicular germ-cell tumours, and help better understand the emerging role of the RB pathway in spermatogenesis and tumorigenesis in the human testis. Oncogene (2000) 19, 4146–4150
- Subjects
CYCLIN-dependent kinases; PHOSPHORYLATION; RETINOBLASTOMA; TUMORS; SPERMATOGENESIS
- Publication
Oncogene, 2000, Vol 19, Issue 36, p4146
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1203769