We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc.
- Authors
Allen, John D; Verhoeven, Els; Domen, Jos; van der Valk, Martin; Berns, Anton
- Abstract
Evidence from proviral tagging experiments has suggested that pim-2 is similar in oncogenic behavior to its well characterized relative pim-1. While the basal expression in tissues differs, both genes are highly expressed in mitogenically stimulated hematopoietic cells and their transcription is induced in response to the same cytokines. Expression of a pim-2 transgene in lymphoid cells predisposed mice to T-cell lymphomas like those promoted by pim-1 transgenes. Moreover, strong collaboration with an Eμ-myc transgene was manifested as pre-B cell leukemia in neonate bi-transgenic animals. Remarkably, this collaboration was attenuated but not prevented by X-inactivation of one of the transgenes. The addition of pim-2 to the fold increases the prominence of the pim proto-oncogene family in tumorigenesis.
- Subjects
TRANSGENES; LYMPHOMAS; TRANSGENIC mice; ONCOGENES
- Publication
Oncogene, 1997, Vol 15, Issue 10, p1133
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1201288