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- Title
Molecular and biochemical pharmacology of the histamine H4 receptor.
- Authors
Leurs, Rob; Chazot, Paul L.; Shenton, Fiona C.; Lim, Herman D.; de Esch, Iwan J. P.
- Abstract
The elucidation of the human genome has had a major impact on histamine receptor research. The identification of the human H4 receptor by several groups has been instrumental for a new appreciation of the role of histamine in the modulation of immune function. In this review, we summarize the historical developments and the molecular and biochemical pharmacology of the H4 receptor.
- Subjects
HISTAMINE receptors; PHARMACOLOGY; INFLAMMATORY mediators; HUMAN genome; HUMAN gene mapping; BINDING sites; RESEARCH; BIOLOGICAL evolution; MATHEMATICAL models; ANIMAL experimentation; RESEARCH methodology; CELL receptors; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; THEORY; IMMUNITY; IMPACT of Event Scale; MOLECULAR structure; LIGANDS (Biochemistry)
- Publication
British Journal of Pharmacology, 2009, Vol 157, Issue 1, p14
- ISSN
0007-1188
- Publication type
journal article
- DOI
10.1111/j.1476-5381.2009.00250.x