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- Title
Glucose-Dependent Insulinotropic Peptide Level Is Associated with the Development of Type 2 Diabetes Mellitus.
- Authors
Sunghwan Suh; Mi Kyoung Park; Duk Kyu Kim; Mi Yeon Kim; Kyu Yeon Hur; Moon-Kyu Lee; Soo Kyoung Kim; Nam H. Cho
- Abstract
Background: Incretin hormone levels as a predictor of type 2 diabetes mellitus have not been fully investigated. Therefore, we measured incretin hormone levels to examine the relationship between circulating incretin hormones, diabetes, and future diabetes development in this study. Methods: A nested case-control study was conducted in a Korean cohort. The study included the following two groups: the control group (n=149), the incident diabetes group (n=65). Fasting total glucagon-like peptide-1 (GLP-1) and total glucose-dependent insulinotropic peptide (GIP) levels were measured and compared between these groups. Results: Fasting total GIP levels were higher in the incident diabetes group than in the control group (32.64±22.68 pmol/L vs. 25.54±18.37 pmol/L, P=0.034). There was no statistically significant difference in fasting total GLP-1 levels between groups (1.14±1.43 pmol/L vs. 1.39±2.13 pmol/L, P=0.199). In multivariate analysis, fasting total GIP levels were associated with an increased risk of diabetes (odds ratio, 1.005; P=0.012) independent of other risk factors. Conclusion: Fasting total GIP levels may be a risk factor for the development of type 2 diabetes mellitus. This association persisted even after adjusting for other metabolic parameters such as elevated fasting glucose, hemoglobin A1c, and obesity in the pre-diabetic period.
- Subjects
GASTRIC inhibitory polypeptide; TYPE 2 diabetes diagnosis
- Publication
Endocrinology & Metabolism, 2016, Vol 31, Issue 1, p134
- ISSN
2093-596X
- Publication type
Article
- DOI
10.3803/EnM.2016.31.1.134