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- Title
Hepatokines as a Link between Obesity and Cardiovascular Diseases.
- Authors
Hye Jin Yoo; Kyung Mook Choi
- Abstract
Non-alcoholic fatty liver disease, which is considered a hepatic manifestation of metabolic syndrome, independently increases the risks of developing cardiovascular disease (CVD) and type 2 diabetes mellitus. Recent emerging evidence suggests that a group of predominantly liver-derived proteins called hepatokines directly affect the progression of atherosclerosis by modulating endothelial dysfunction and infiltration of inflammatory cells into vessel walls. Here, we summarize the role of the representative hepatokines fibroblast growth factor 21, fetuin-A, and selenoprotein P in the progression of CVD.
- Subjects
OBESITY; BODY weight; CARDIOVASCULAR diseases; CARDIOVASCULAR system; HEART diseases
- Publication
Diabetes & Metabolism Journal, 2015, Vol 39, Issue 1, p10
- ISSN
2233-6079
- Publication type
Article
- DOI
10.4093/dmj.2015.39.1.10