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- Title
Insulin resistance is inversely related to prostate cancer: A prospective study in Northern Sweden.
- Authors
Stocks, Tanja; Lukanova, Annekatrin; Rinaldi, Sabina; Biessy, Carine; Dossus, Laure; Lindahl, Bernt; Hallmans, Göran; Kaaks, Rudolf; Stattin, Pär
- Abstract
Factors related to insulin resistance have been implicated in prostate cancer development, however, few analytical studies support such an association. We performed a case control study on 392 prostate cancer cases and 392 matched controls nested in a prospective cohort in Northern Sweden. Plasma concentrations of C-peptide, leptin, glycated haemoglobin (HbA1c) and fasting and post-load glucose were analysed and homeostatic model assessment of insulin resistance (HOMA-IR) was calculated. Conditional logistic regression analyses were used to calculate odds ratios (OR) of prostate cancer. High levels of C-peptide, HOMA-IR, leptin and HbA1c were associated with significant decreases in risk of prostate cancer, with ORs for top vs. bottom quartile for C-peptide of 0.59 (95% Confidence Interval [CI], 0.40-0.89; p
- Publication
International Journal of Cancer, 2007, Vol 120, Issue 12, p2678
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.22587