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- Title
Small‐Diameter PLCL/PCL Nanofiber Grafted TSF Vascular Scaffolds with a Double‐Layer Structure for Vascular Tissue Engineering.
- Authors
Shao, Weili; Cui, Chen; Xiong, Junpeng; Wang, Ling; Zhao, Xu; Hou, Yijun; Chang, Shuzhen; Sun, Ning; Zhang, Yuting; Gao, Yanfei; Ni, Qingqing; Liu, Fan; He, Jianxin
- Abstract
Successful construction of small‐diameter double‐layer vascular scaffolds (SDVSs) whose inner diameters are less than 1.5 mm, especially those with multilayer mimic structures, remains a challenge in vascular tissue engineering. In this study, poly(L‐lactide‐co‐caprolactone) (PLCL)/poly(Ɛ‐caprolactone) (PCL)/tussah silk fibroin (TSF) SDVSs with a double‐layer structure are prepared by one‐step method based on friction twisting core‐spun electrospinning technology. The constructed PLCL/PCL SDVSs grafted TSF have an obvious double‐layer structure; tube wall thickness 524 ± 28 µm; and inner tube diameter 1390 ± 40 µm. Compared with traditional nanofiber vascular scaffolds (TS), the axial and radial tensile strengths of PLCL/PCL SDVSs grafted TSF increase by 86% and 34%, respectively. They also show good scaffold elastic recovery and burst pressure (BP) (8505 ± 875 mmHg). Compared with the PLCL/PCL SDVSs, the inner and outer layers of PLCL/PCL SDVSs grafted TSF show good hydrophilicity and protein adsorption performance. The in vitro cell viability results indicate that the inner and outer layers of PLCL/PCL SDVSs grafted TSF show enhanced proliferation and adhesion of vein endothelial cells (VECs) and smooth muscle cells (SMCs), respectively. Therefore, the successful preparation of PLCL/PCL SDVSs grafted TSF provides more possibilities for the clinical transplantation of small‐diameter vascular scaffolds.
- Subjects
TISSUE engineering; VASCULAR grafts; TISSUE scaffolds; SILK fibroin; SMOOTH muscle; MUSCLE cells
- Publication
Macromolecular Materials & Engineering, 2021, Vol 306, Issue 11, p1
- ISSN
1438-7492
- Publication type
Article
- DOI
10.1002/mame.202100462