We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of Terminal Sterilization on PEG-Based Bioresorbable Polymers Used in Biomedical Applications.
- Authors
Bhatnagar, Divya; Dube, Koustubh; Damodaran, Vinod B.; Subramanian, Ganesan; Aston, Kenneth; Halperin, Frederick; Mao, Meiyu; Pricer, Kurt; Murthy, N. Sanjeeva; Kohn, Joachim
- Abstract
The effects of ethylene oxide (EO), vaporized hydrogen peroxide (VHP), gamma (γ) radiation, and electron-beam (E-beam) on the physiochemical and morphological properties of medical device polymers are investigated. Polymers with ether, carbonate, carboxylic acid, amide and ester functionalities are selected from a family of poly(ethylene glycol) (PEG) containing tyrosine-derived polycarbonates (TyrPCs) to include slow, medium, fast, and ultra-fast degrading polymers. Poly(lactic acid) (PLA) is used for comparison. Molecular weight ( Mw) of all tested polymers decreases upon gamma and E-beam, and this effect becomes more pronounced at higher PEG content. Gamma sterilization increases the glass transition temperature of polymers with high PEG content. EO esterifies the carboxylic acid groups in desaminotyrosol-tyrosine (DT) and causes significant degradation. VHP causes hydroxylation of the phenyl ring, and hydrolytic degradation. This study signifies the importance of the chemical composition when selecting a sterilization method, and provides suggested conditions for each of the sterilization methods.
- Subjects
BIOPOLYMERS; CHEMICAL synthesis; POLYETHYLENE glycol; HYDROXYLATION; GLASS transition temperature; CARBOXYLIC acids
- Publication
Macromolecular Materials & Engineering, 2016, Vol 301, Issue 10, p1211
- ISSN
1438-7492
- Publication type
Article
- DOI
10.1002/mame.201600133