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- Title
Synthesis of 1'-Acetoxychavicol Acetate (ACA) Analogues and Their Inhibitory Activities against Methicillin-resistant Staphylococcus aureus.
- Authors
Anuar, Nursyazwani; Mohamad Taib, Mohamad Nurul Azmi; Hanafiah, Khayriyyah Mohd; Al Shammary, Aemen Ali Kudayr; Shalan, Nur Shazieyatul Nadiah; Che Humaidi, Siti Nur Izaty; Awang, Khalijah
- Abstract
A series of 1'-acetoxychavicol acetate analogues were synthesised and evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) using broth microdilution technique. The minimum inhibitory concentration (MIC) was used to determine whether the compounds had potential as inhibitory agents against the MRSA ATCC 43300, and the compounds with antimicrobial potential (<2000 µg ml-1) were tested for minimum bactericidal concentration (MBC). Based on this assay, compound 1 exhibited potent antimicrobial activity with MIC value of 250 µg ml-1. Meanwhile, compounds 2 and 13 showed the moderate activity with MIC values of 500 µg ml-1, respectively.
- Subjects
METHICILLIN-resistant staphylococcus aureus; ACETATES
- Publication
Journal of Physical Science, 2020, Vol 31, Issue 3, p101
- ISSN
1675-3402
- Publication type
Article
- DOI
10.21315/jps2020.31.3.8