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- Title
Thermodynamics of dissolution and infrared-spectroscopy of solid dispersions of phenacetin.
- Authors
Gerasimov, Alexander V.; Varfolomeev, Mikhail A.; Ziganshin, Marat A.; Gorbatchuk, Valery V.; Rakipov, Il'naz T.; Klimovitskii, Alexander E.; Usmanova, Liana S.
- Abstract
In this work enthalpies of dissolution in water of polyethylene glycols (PEGs) having an average molecular weight of 1000 and 1400, Pluronic-F127, phenacetin as well as the composites prepared from them were measured using solution calorimetry at 298.15 K. Intermolecular interaction energies of polymer-phenacetin were calculated on the basis of an additive scheme. It was shown that for mixtures with high content of polymer (>90 wt%) Pluronic-F127 has the highest solubilizing effect, while for mixtures with (4-6):1 polymer: phenacetin ratio the best solubilizing agent is PEG-1400. Infraredspectra showed a decrease of the number of self-associated molecules of phenacetin with increasing of polymer content in the composites. The obtained results enabled us to identify the features of intermolecular interactions of polymers with a model hydrophobic drug and may be used for optimizing the conditions for preparing solid dispersions based on hydrophilic polymers.
- Subjects
PHENACETIN; THERMODYNAMICS research; DISSOLUTION (Chemistry)
- Publication
Journal of Advanced Pharmaceutical Technology & Research, 2016, Vol 7, Issue 1, p6
- ISSN
2231-4040
- Publication type
Article
- DOI
10.4103/2231-4040.169874