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- Title
ALKBH5-mediated m<sup>6</sup>A modification of lincRNA LINC02551 enhances the stability of DDX24 to promote hepatocellular carcinoma growth and metastasis.
- Authors
Zhang, Hongwei; Liu, Yachong; Wang, Wei; Liu, Furong; Wang, Weijian; Su, Chen; Zhu, He; Liao, Zhibin; Zhang, Bixiang; Chen, Xiaoping
- Abstract
As the most important RNA epigenetic regulation in eukaryotic cells, N6-metheyladenosine (m6A) modification has been demonstrated to play significant roles in cancer progression. However, this modification in long intergenic non-coding RNAs (lincRNAs) and the corresponding functions remain elusive. Here, we showed a lincRNA LINC02551 was downregulated by AlkB Homolog 5 (ALKBH5) overexpression in a m6A-dependent manner in hepatocellular carcinoma (HCC). Functionally, LINC02551 was required for the growth and metastasis of HCC. Mechanistically, LINC02551, a bona fide m6A target of ALKBH5, acted as a molecular adaptor that blocked the combination between DDX24 and a E3 ligase TRIM27 to decrease the ubiquitination and subsequent degradation of DDX24, ultimately facilitating HCC growth and metastasis. Thus, ALKBH5-mediated LINC02551 m6A methylation was required for HCC growth and metastasis.
- Publication
Cell Death & Disease, 2022, Vol 13, Issue 11, p1
- ISSN
2041-4889
- Publication type
Article
- DOI
10.1038/s41419-022-05386-4