We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of Korean Red Ginseng as an adjuvant treatment for women with residual symptoms of major depression.
- Authors
Jeong, Hyun‐Ghang; Ko, Young‐Hoon; Oh, So‐Young; Han, Changsu; Kim, Taehee; Joe, Sook‐Haeng
- Abstract
Introduction Around 20% of patients with major depression experience residual symptoms. Ginseng has shown potential antidepressant effects in some animal studies and in patients with stress-related somatic symptoms. Therefore, we investigated the effectiveness and tolerability of Korean Red Ginseng adjuvant treatment in patients with residual symptoms of major depression. Methods In this eight-week prospective study, 35 female outpatients aging from 18 to 65 years (45.1 ± 9.5), who were remitted from major depression with residual symptoms, were given Korean Red Ginseng at doses of 3 g/day. The Depression Residual Symptom Scale ( DRSS) and Montgomery-Åsberg Depression Rating Scale ( MADRS) were administrated to evaluate depressive symptoms. The general severity of symptoms was assessed by a clinician using the Clinical Global Impressions Scale for Severity ( CGI- S). The Depression and Somatic Symptom Scale ( DSSS) was also used to evaluate somatic symptoms in the subjects. This trial is registered at Clinical.gov, number NCT01496248. Results Subjects reported significant decrease in depressive symptoms on the DRSS ( P < 0.05) and MADRS ( P < 0.01) decreased significantly over the eight-week period. The scores on the CGI- S, an objective measurement of symptoms, showed significant improvement in the severity of illness ( P < 0.001). Somatic symptoms on the DSSS also attenuated significantly during the study period ( P < 0.05). Discussion These results suggest that Korean Red Ginseng is efficacious as an adjuvant treatment for patients experiencing residual symptoms of major depression. Future placebo-controlled research is required to confirm our results.
- Subjects
SOUTH Korea; DEPRESSION in women; THERAPEUTIC use of ginseng; SYMPTOMS; PUBLIC health; SEVERITY of illness index; THERAPEUTICS
- Publication
Asia-Pacific Psychiatry, 2015, Vol 7, Issue 3, p330
- ISSN
1758-5864
- Publication type
Article
- DOI
10.1111/appy.12169