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- Title
Selenomethionine Inhibited HADV-Induced Apoptosis Mediated by ROS through the JAK-STAT3 Signaling Pathway.
- Authors
Li, Chuqing; Liu, Xia; Li, Jiali; Lai, Jia; Su, Jingyao; Zhu, Bing; Gao, Buyun; Li, Yinghua; Zhao, Mingqi
- Abstract
Adenovirus (HAdV) can cause severe respiratory infections in children and immunocompromised patients. There is a lack of specific therapeutic drugs for HAdV infection, and the study of anti-adenoviral drugs has far-reaching clinical implications. Elemental selenium can play a specific role as an antioxidant in the human immune cycle by non-specifically binding to the amino acid methionine in body proteins. Methods: The antiviral mechanism of selenomethionine was explored by measuring cell membrane status, intracellular DNA status, cytokine secretion, mitochondrial membrane potential, and ROS production. Conclusions: Selenomethionine improved the regulation of ROS-mediated apoptosis by modulating the expression of Jak1/2, STAT3, and BCL-XL, which led to the inhibition of apoptosis. It is anticipated that selenomethionine will offer a new anti-adenoviral therapeutic alternative.
- Subjects
MITOCHONDRIAL membranes; CARRIER proteins; CELL membranes; RESEARCH funding; APOPTOSIS; METHIONINE; CELLULAR signal transduction; TREATMENT effectiveness; ANTIVIRAL agents; JANUS kinases; REACTIVE oxygen species; CYTOKINES; DNA virus diseases; PHARMACODYNAMICS
- Publication
Nutrients, 2024, Vol 16, Issue 12, p1966
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16121966