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- Title
Purine Intake and All-Cause Mortality in Ovarian Cancer: Results from a Prospective Cohort Study.
- Authors
Du, Zongda; Gong, Tingting; Wei, Yifan; Zheng, Gang; Zhao, Junqi; Zou, Bingjie; Qin, Xue; Yan, Shi; Liu, Fanghua; Xiao, Qian; Wu, Qijun; Gao, Song; Zhao, Yuhong
- Abstract
Background: Current biological evidence suggests that purine involvement in purine metabolism may contribute to the development and progression of ovarian cancer (OC), but the epidemiological association is currently unknown. Methods: A total of 703 newly diagnosed patients with OC aged 18–79 years were included in this prospective cohort study. Utilizing a verified food-frequency questionnaire, the participants' dietary consumption was gathered. Using medical records and ongoing follow-up, the deaths up until 31 March 2021 were determined. To assess the hazard ratios (HRs) and 95% confidence intervals (CIs) of purine intake with OC mortality, Cox proportional-hazard models were utilized. Results: During the median follow-up of 31 months (interquartile: 20–47 months), 130 deaths occurred. We observed an improved survival for the highest tercile of total purine intake compared with the lowest tercile (HR = 0.39, 95% CI = 0.19–0.80; p trend < 0.05), and this protective association was mainly attributed to xanthine intake (HR = 0.52, 95% CI = 0.29–0.94, p trend < 0.05). Additionally, we observed a curving relationship in which OC mortality decreased with total purine intake, and the magnitude of the decrease was negatively correlated with intake (p non-linear < 0.05). Significant inverse associations were also observed in subgroup analyses and sensitivity analyses according to demographic and clinical characteristics. Moreover, we observed that xanthine intake and hypoxanthine intake had a multiplicative interaction with ER and PR expression (p < 0.05), respectively. Conclusion: A high total purine and xanthine intake was linked to a lower risk of OC mortality. Further clarification of these findings is warranted.
- Subjects
OVARIAN tumors; CONFIDENCE intervals; PURINES; FOOD consumption; IMMUNOHISTOCHEMISTRY; ACQUISITION of data; RISK assessment; XANTHINE; QUESTIONNAIRES; MEDICAL records; SURVIVAL analysis (Biometry); DEMOGRAPHY; BODY mass index; ELECTRONIC health records; ODDS ratio; LONGITUDINAL method; PROPORTIONAL hazards models
- Publication
Nutrients, 2023, Vol 15, Issue 4, p931
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15040931