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- Title
Dietary Antioxidant Capacity Promotes a Protective Effect against Exacerbated Oxidative Stress in Women Undergoing Adjuvant Treatment for Breast Cancer in a Prospective Study.
- Authors
Reitz, Luiza Kuhnen; Schroeder, Jaqueline; Longo, Giana Zarbato; Boaventura, Brunna Cristina Bremer; Di Pietro, Patricia Faria
- Abstract
Breast cancer (Bca) is the most common type of cancer among women worldwide, and oxidative stress caused by adjuvant treatment may be decreased by antioxidant intake. The aim of this study is to investigate the associations between Dietary antioxidant Capacity (DaC) and oxidation and antioxidant biomarkers in women undergoing adjuvant treatment (AT) for Bca. This prospective study had a sample of 70 women (52.2 ± 10.7 y). DaC (mmol/g) was calculated using nutritional data obtained from a Food Frequency Questionnaire, and blood was collected to measure the oxidation and antioxidant biomarkers at baseline (T0), and after AT (T1). Carbonylated protein levels were inversely associated with DaC at T1 (p = 0.004); women showed an increased risk of having increment on lipid hydroperoxides and thiobarbituric acid reactive substances (TBARS), and decrement on ferric reducing antioxidant power (FRAP) and reduced glutathione after AT, in response to lowered DaC (p < 0.05). Carbonylated proteins, TBARS and FRAP levels remained stable between the periods for women at the 3rd DaC tertile at T1, differentiating them from those at the 1st tertile, who showed negative changes in these biomarkers (p < 0.04). DaC may be beneficial for women undergoing AT for Bca, since it promoted a reduction in oxidative stress.
- Subjects
THERAPEUTIC use of antioxidants; GLUTATHIONE; ANTIOXIDANTS; OXIDATIVE stress; CANCER patients; QUESTIONNAIRES; ALDEHYDES; DESCRIPTIVE statistics; RADIOTHERAPY; COMBINED modality therapy; TUMOR markers; BREAST tumors; LONGITUDINAL method; LIPIDS
- Publication
Nutrients, 2021, Vol 13, Issue 12, p4324
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13124324