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- Title
Vitamin K Effects on Gas6 and Soluble Axl Receptors in Intensive Care Patients: An Observational Screening Study.
- Authors
Schött, Ulf; Augustsson, Cecilia; Lilover, Luukas; Nilsson, Caroline Ulfsdotter; Walther-Sturesson, Louise; Kander, Thomas
- Abstract
Growth arrest-specific gene 6 protein (Gas6) is avitamin K-dependent tissue bound protein. Gas6 has been shown to promote growth and therapy resistance among different types of cancer as well as thromboembolism. The aim of this prospective screening study: ClinicalTrials.gov; Identifier: NTC3782025, was to evaluate the effects of intravenously administered vitamin K1 on Gas6 and its soluble (s)Axl receptor plasma levels in intensive care patients. Vitamin K1 was intravenously injected in non-warfarin treated patients with prolonged Owren prothrombin time international normalized ratio (PT-INR) > 1.2 and blood samples were retrieved before and 20–28 h after injection. Citrate plasma samples from 52 intensive care patients were analysed for different vitamin K dependent proteins. There was a significant, but small increase in median Gas6. Only one patient had a large increase in sAxl, but overall, no significant changes in sAxl Gas6 did not correlate to PT-INR, thrombin generation assay, coagulation factors II, VII, IX and X, but to protein S and decarboxylated matrix Gla protein (dp-ucMGP). In conclusion, there was a small increase in Gas6 over 20–28 h. The pathophysiology and clinical importance of this remains to be investigated. To verify a true vitamin K effect, improvement of Gas6 carboxylation defects needs to be studied.
- Subjects
SWEDEN; PROTHROMBIN time; INTENSIVE care units; INTRAVENOUS therapy; ACADEMIC medical centers; CLINICAL trials; BLOOD plasma; CELL receptors; BLOOD collection; CITRATES; ENZYME-linked immunosorbent assay; DESCRIPTIVE statistics; INTERNATIONAL normalized ratio; DATA analysis software; VITAMIN K; LONGITUDINAL method; THROMBIN; BLOOD
- Publication
Nutrients, 2021, Vol 13, Issue 11, p4101
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13114101