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- Title
Association of Body Weight Variability with Adverse Cardiovascular Outcomes in Patients with Pre-Dialysis Chronic Kidney Disease.
- Authors
Suh, Sang Heon; Oh, Tae Ryom; Choi, Hong Sang; Kim, Chang Seong; Bae, Eun Hui; Park, Sue K.; Kim, Yong-Soo; Kim, Yeong Hoon; Choi, Kyu Hun; Oh, Kook-Hwan; Ma, Seong Kwon; Kim, Soo Wan
- Abstract
To investigate the association of body weight variability (BWV) with adverse cardiovascular (CV) outcomes in patient with pre-dialysis chronic kidney disease (CKD), a total of 1867 participants with pre-dialysis CKD from Korean Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) were analyzed. BWV was defined as the average absolute difference between successive values. The primary outcome was a composite of non-fatal CV events and all-cause mortality. Secondary outcomes were fatal and non-fatal CV events and all-cause mortality. High BWV was associated with increased risk of the composite outcome (adjusted hazard ratio (HR) 1.745, 95% confidence interval (CI) 1.065 to 2.847) as well as fatal and non-fatal CV events (adjusted HR 1.845, 95% CI 1.136 to 2.996) and all-cause mortality (adjusted HR 1.861, 95% CI 1.101 to 3.145). High BWV was associated with increased risk of fatal and non-fatal CV events, even in subjects without significant body weight gain or loss during follow-up periods (adjusted HR 2.755, 95% CI 1.114 to 6.813). In conclusion, high BWV is associated with adverse CV outcomes in patients with pre-dialysis CKD.
- Subjects
CHRONIC kidney failure; EVALUATION of medical care; CAUSES of death; BODY weight; CONFIDENCE intervals; CARDIOVASCULAR diseases; WEIGHT gain; DESCRIPTIVE statistics; WEIGHT loss; HEMODIALYSIS
- Publication
Nutrients, 2021, Vol 13, Issue 10, p3381
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13103381