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- Title
Plasma B Vitamers: Population Epidemiology and Parent-Child Concordance in Children and Adults.
- Authors
Andraos, Stephanie; Jones, Beatrix; Wall, Clare; Thorstensen, Eric; Kussmann, Martin; Cameron-Smith, David; Lange, Katherine; Clifford, Susan; Saffery, Richard; Burgner, David; Wake, Melissa; O'Sullivan, Justin; Nexø, Ebba
- Abstract
Scope: B vitamers are co-enzymes involved in key physiological processes including energy production, one-carbon, and macronutrient metabolism. Studies profiling B vitamers simultaneously in parent–child dyads are scarce. Profiling B vitamers in parent–child dyads enables an insightful determination of gene–environment contributions to their circulating concentrations. We aimed to characterise: (a) parent–child dyad concordance, (b) generation (children versus adults), (c) age (within the adult subgroup (age range 28–71 years)) and (d) sex differences in plasma B vitamer concentrations in the CheckPoint study of Australian children. Methods and Results: 1166 children (11 ± 0.5 years, 51% female) and 1324 parents (44 ± 5.1 years, 87% female) took part in a biomedical assessment of a population-derived longitudinal cohort study: The Growing Up in Australia's Child Health CheckPoint. B vitamer levels were quantified by UHPLC/MS-MS. B vitamer levels were weakly concordant between parent–child pairs (10–31% of variability explained). All B vitamer concentrations exhibited generation-specificity, except for flavin mononucleotide (FMN). The levels of thiamine, pantothenic acid, and 4-pyridoxic acid were higher in male children, and those of pantothenic acid were higher in male adults compared to their female counterparts. Conclusion: Family, age, and sex contribute to variations in the concentrations of plasma B vitamers in Australian children and adults.
- Subjects
AUSTRALIA; BIOMARKERS; PYRIDINE; HIGH performance liquid chromatography; PANTOTHENIC acid; GENETICS; AGE distribution; NUTRITIONAL requirements; VITAMIN B complex; SEX distribution; MASS spectrometry; VITAMIN B1; POPULATION health; METABOLITES; PARENTS; LONGITUDINAL method
- Publication
Nutrients, 2021, Vol 13, Issue 3, p821
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13030821