We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Efficacy of Methylphenidate Among Children with Autism and Symptoms of Attention-Deficit Hyperactivity Disorder.
- Authors
Handen, Benjamin L.; Johnson, Cynthia R.; Lubetsky, Martin
- Abstract
Thirteen children (ages 5.6 to 11.2 years) with autism and symptoms of attention-deficit hyperactivity disorder (ADHD) participated in a double-blind, placebo-controlled crossover study of methylphenidate (0.3 and 0.6 mg/kg per dose). Eight subjects responded positively, based upon a minimum 50% decrease on the Conners Hyperactivity Index. Ratings of stereotypy and inappropriate speech, which are often associated with autistic core features, also decreased. However, no changes were found on the Child Autism Rating Scale, a global assessment of autistic symptomotology. Significant adverse side effects occurred in some children including social withdrawal and irritability, especially at the 0.6 mg/kg dose. Results suggest that methylphenidate can be efficacious for children with autism and ADHD symptoms. However, this group of children seems to be particularly susceptible to adverse side effects.
- Subjects
AUTISM; ATTENTION-deficit hyperactivity disorder; STIMULANTS
- Publication
Journal of Autism & Developmental Disorders, 2000, Vol 30, Issue 3, p245
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1023/A:1005548619694