We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Risk for Distant Recurrence of Breast Cancer Detected by Mammography Screening or Other Methods.
- Authors
Joensuu, Heikki; Lehtimäki, Tiina; Holli, Kaija; Elomaa, Liisa; Turpeenniemi-Hujanen, Taina; Kataja, Vesa; Anttila, Ahti; Lundin, Mikael; Isola, Jorma; Lundin, Johan
- Abstract
Context Selection of systemic adjuvant therapies for women diagnosed as having breast cancer is based on risk estimations for cancer recurrence. In such estimations, tumors detected by mammography screening are considered to be associated with a similar risk of recurrence as tumors of similar size found by other methods. Objective To compare the risk of recurrence and survival among women with cancerous tumors detected by mammography screening compared with other methods (outside of screening). Design, Setting, and Patients Retrospective study comparing clinical, histopathological, and biological features of cancerous tumors detected by mammography screening compared with tumors detected outside of screening. Women diagnosed as having breast cancer in 1991 or 1992 were identified from the Finnish Cancer Registry (n = 2842). The median follow-up time was 9.5 years. Cancer biological variables were analyzed from tumor tissue microarrays using immunohistochemistry or in situ hybridization and included ERBB2, TP53, and MK167 expression and ERBB2 amplification data. Main Outcome Measures Univariate and multivariate analyses of potential risk factors for distant recurrence of breast cancer and 10-year survival. Results Of the 1983 women with unilateral invasive breast cancer, data on tumor diameter were available for 1918 women. Women with cancerous tumors detected by mammography screening had better estimated 10-year distant disease-free survival than women with tumors found outside of screening (tumor size of ≤10 mm [n = 386] 92% vs 85% [P = .04]; 11-20 mm [n = 808] 88% vs 76% [P<.001]; 21-30 mm [n = 409] 86% vs 63% [P = .008]; > 30 mm [n = 315] 68% vs 50% [P = .12], respectively). In a Cox multivariate model that included cancer biological factors, the relative hazard ratio for distant recurrence among women with tumors detected outside of screening (HR, 1.90; 95% confidence interval, 1.15-3.11) was significantly higher than among women with tumors det...
- Subjects
CANCER in women; TUMORS; BREAST cancer; WOMEN'S health; DIAGNOSIS; ONCOLOGY; PROGNOSIS; FORECASTING; MEDICAL screening
- Publication
JAMA: Journal of the American Medical Association, 2004, Vol 292, Issue 9, p1064
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.292.9.1064