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- Title
Myocardial Perfusion Imaging for Evaluation and Triage of Patients With Suspected Acute Cardiac Ischemia: A Randomized Controlled Trial.
- Authors
Udelson, James E.; Beshansky, Joni R.; Ballin, Daniel S.; Feldman, James A.; Griffith, John L.; Heller, Gary V.; Hendel, Robert C.; Pope, J. Hector; Ruthazer, Robin; Spiegler, Ethan J.; Woolard, Robert H.; Handler, Jonathan; Selker, Harry P.
- Abstract
Context: Observational studies of acute myocardial perfusion imaging in emergency department (ED) patients with chest pain have suggested high sensitivity and negative predictive value for acute cardiac ischemia, but use of this method has not been prospectively tested. Objective: To assess whether incorporating acute resting perfusion imaging into an ED evaluation strategy for patients with suspected acute ischemia but no initial electrocardiogram (ECG) changes diagnostic of acute ischemia improves clinical decision making for initial ED triage. Design, Setting, and Patients: Prospective, randomized controlled trial conducted at 7 academic medical centers and community hospitals between July 1997 and May 1999 among 2475 adult ED patients with chest pain or other symptoms suggestive of acute cardiac ischemia and with normal or nondiagnostic initial ECG results. Intervention: Patients were randomly assigned to receive either the usual ED evaluation strategy (n = 1260) or the usual strategy supplemented with results from acute resting myocardial perfusion imaging using single-photon emission computed tomography with injection of 20 to 30 mCi of Tc-99m sestamibi (n = 1215), interpreted in real time by local staff physicians and with results provided to the ED physician for incorporation into clinical decision making. Main Outcome Measure: Appropriateness of triage decision either to admit to hospital/observation or to discharge directly home from the ED. Results: Among patients with acute cardiac ischemia (ie, acute myocardial infarction [MI] or unstable angina; n = 329), there were no differences in ED triage decisions between those receiving standard evaluation and those whose evaluation was supplemented by a sestamibi scan. Among patients with acute MI (n = 56), 97% vs 96% were hospitalized (relative risk [RR], 1.00; 95% confidence interval [CI], 0.89-1.12), and among those with unstable angina (n = 273), 83% vs 81% were hospitalized (RR, 0.98; 95% CI, 0.87-1...
- Subjects
MYOCARDIAL infarction; CORONARY disease; CHEST disease diagnosis; ISCHEMIA; ELECTROCARDIOGRAPHY; MEDICAL emergencies; MEDICAL centers; EMERGENCY medical services
- Publication
JAMA: Journal of the American Medical Association, 2002, Vol 288, Issue 21, p2693
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.288.21.2693