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- Title
Impact of a comprehensive geriatric assessment on decision‐making in older patients with hematological malignancies.
- Authors
Garric, Marie; Sourdet, Sandrine; Cabarrou, Bastien; Steinmeyer, Zara; Gauthier, Martin; Ysebaert, Loïc; Beyne‐Rauzy, Odile; Gerard, Stephane; Lozano, Stephanie; Brechemier, Delphine; Filleron, Thomas; Mourey, Loïc; Balardy, Laurent
- Abstract
Objective: Hematological treatment decisions in older adults with hematological malignancies are complex. Our objective is to study the impact of a comprehensive geriatric assessment on hematological treatment decision in older patients and the factors associated with change in treatment plan. Methods: We conducted a cross‐sectional analysis of patients aged 65 years and above with hematological malignancies, hospitalized between 2008 and 2019 at the University Cancer Institute of Toulouse. They were assessed by a geriatrician/nurse team using a comprehensive geriatric assessment (CGA). A penalized logistic regression model with elastic net regularization was used to identify factors associated with change in hematological treatment plan. Results: A total of 424 patients were included. Main hematological malignancies were lymphoma (36.1 %), acute myeloid leukemia (26.9 %) and myelodysplastic syndrome (19.8%). Change in hematological treatment plan was suggested after CGA for 92 patients (21.7%). Factors associated with change in treatment plan were functional impairment according to ADL and IADL scale, mobility impairment, the presence of comorbidity defined by the Charlson score >1 and increasing age. Conclusion: A CGA has a significant impact on hematological treatment decision in older patients. Functional and mobility impairment, comorbidities and age are predictive factors of change in treatment plan.
- Subjects
TOULOUSE (France); OLDER patients; GERIATRIC assessment; ACUTE myeloid leukemia; OLDER people; MYELODYSPLASTIC syndromes; GERIATRICIANS
- Publication
European Journal of Haematology, 2021, Vol 106, Issue 5, p616
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.13570