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- Title
Normal Composition of the Major Lipids and the Distribution of Their Fatty Acids in Central Nervous System Myelin further Discriminate mld from Shiverer Mice.
- Authors
Fressinaud, C.; Sarliève, L.L.; Cassagne, C.; Vincendon, G.; Matthieu, J.M.
- Abstract
The primary defect in myelin deficiency (mld), an autosomal recessive mutation in mice with severe hypomyelination of the central nervous system (CNS), is a reduction in the synthesis of myelin basic protein (MBP) due to reduced amounts of MBP-specific mRNA. The present study was performed to determine whether alterations of myelin lipid composition might be associated with this defect. Although a 20-fold reduction of myelin was found in mld brain, the lipid/protein and the phospholipid/sulfatide ratios of purified myelin were unchanged. The analysis of polar lipids demonstrated no striking difference. However, phosphatidylethanolamine (including plasmalogens of the ethanolamine type) was decreased by 7.7% in mld. Fatty acids of total and polar lipids (phospholipids + glycolipids) exhibited a slight decrease in 20:1(n-11) and 20:1(n-9). In conclusion, these results further differentiate mld from its allele shiverer, which shares with mld a dramatic reduction of MBP and absence of major dense line but, in contrast, presents other important biochemical differences in CNS myelin. Copyright © 1990 S. Karger AG, Basel
- Publication
Developmental Neuroscience, 1990, Vol 12, Issue 1, p61
- ISSN
0378-5866
- Publication type
Article
- DOI
10.1159/000111835