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- Title
THE PROTECTIVE ROLE OF N-ACETYLCYSTEINE IN AN EXPERIMENTAL RENAL ISCHEMIA-REPERFUSION MODEL ON WISTAR RATS.
- Authors
Airizer, Melania; Moldovan, Remus; Decea, Nicoleta; Mureşan, Adriana; Căprioară, Mirela Gherman
- Abstract
Many studies have demonstrated that oxidative stress plays an important role in ischemic acute renal failure. The aim of the present study was to investigate the effects of N Acetyl-cystein (ACC) on renal function and the oxidative stress in a rat model of renal ischemia-reperfusion (IR) injury. Histological analysis of kidney tissue was performed. Renal IR was performed by clamping the unilateral renal artery for 20 min followed by 24 h of reperfusion. ACC was administered 72, 24 and 3h prior to IR and the same dose was given 3 h, 24 and 72 h after IR. Treatment groups were: control group, IR group and IR-ACC group. Renal function was assessed by measuring plasma creatinine on days 1, 3 and 7 after IR. Malondialdehyde (MDA) was measured on days 1, 3, 7 after IR. Superoxide dismutase (SOD), catalase and gluthatione were measured as antioxidative markers. IR produced elevated levels of MDA and increased creatinine compared with control group (p<0.05). SOD and catalase levels were lower in IR compared with control group. ACC reduced elevated levels of MDA, increased SOD, catalase and gluthatione levels (P<0.05) and attenuated renal dysfunction. These results demonstrate the antioxidant effect of ACC in attenuating renal IR injury.
- Subjects
MANGANESE enzymes; ISCHEMIA; OXIDATIVE stress; HETEROCYCLIC compounds; MALONIC acid; ACUTE kidney failure
- Publication
Studia Universitatis Vasile Goldis Seria Stiintele Vietii (Life Sciences Series), 2010, Vol 20, Issue 1, p13
- ISSN
1584-2363
- Publication type
Article