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Insulin-cholera toxin binding unit conjugate: A hybrid molecule with insulin biological activity and cholera toxin binding specificity.
Published in:
Journal of Cellular Physiology, 1983, v. 115, n. 2, p. 151, doi. 10.1002/jcp.1041150208
By:
- Roth, Richard A.;
- Maddux, Betty
Publication type:
Article
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes.
Published in:
Nature Genetics, 2005, v. 37, n. 8, p. 863, doi. 10.1038/ng1604
By:
- Meyre, David;
- Bouatia-Naji, Nabila;
- Tounian, Agnès;
- Samson, Chantal;
- Lecoeur, Cécile;
- Vatin, Vincent;
- Ghoussaini, Maya;
- Wachter, Christophe;
- Hercberg, Serge;
- Charpentier, Guillaume;
- Patsch, Wolfgang;
- Pattou, François;
- Charles, Marie-Aline;
- Tounian, Patrick;
- Clément, Karine;
- Jouret, Béatrice;
- Weill, Jacques;
- Maddux, Betty A.;
- Goldfine, Ira D.;
- Walley, Andrew
Publication type:
Article
Insulin Resistance Induced by Hyperinsulinemia Coincides with a Persistent Alteration at the Insulin Receptor Tyrosine Kinase Domain.
Published in:
PLoS ONE, 2014, v. 9, n. 9, p. 1, doi. 10.1371/journal.pone.0108693
By:
- Catalano, Karyn J.;
- Maddux, Betty A.;
- Szary, Jaroslaw;
- Youngren, Jack F.;
- Goldfine, Ira D.;
- Schaufele, Fred
Publication type:
Article
Improved Glucose Metabolism In Vitro and In Vivo by an Allosteric Monoclonal Antibody That Increases Insulin Receptor Binding Affinity.
Published in:
PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0088684
By:
- Corbin, John A.;
- Bhaskar, Vinay;
- Goldfine, Ira D.;
- Bedinger, Daniel H.;
- Lau, Angela;
- Michelson, Kristen;
- Gross, Lisa M.;
- Maddux, Betty A.;
- Kuan, Hua F.;
- Tran, Catarina;
- Lao, Llewelyn;
- Handa, Masahisa;
- Watson, Susan R.;
- Narasimha, Ajay J.;
- Zhu, Shirley;
- Levy, Raphael;
- Webster, Lynn;
- Wijesuriya, Sujeewa D.;
- Liu, Naichi;
- Wu, Xiaorong
Publication type:
Article
Insulin Resistance in Non-Obese Subjects Is Associated with Activation of the JNK Pathway and Impaired Insulin Signaling in Skeletal Muscle.
Published in:
PLoS ONE, 2011, v. 6, n. 5, p. 1, doi. 10.1371/journal.pone.0019878
By:
- Masharani, Umesh B.;
- Maddux, Betty A.;
- Xiaojuan Li;
- Sakkas, Giorgos K.;
- Mulligan, Kathleen;
- Schambelan, Morris;
- Goldfine, Ira D.;
- Youngren, Jack F.
Publication type:
Article
Effects of Testosterone and 5β-Androstanes on in Vitro Erythroid Colony Formation in Mouse Bone Marrow<sup>1</sup>.
Published in:
Proceedings of the Society for Experimental Biology & Medicine, 1981, v. 167, n. 1, p. 51, doi. 10.3181/00379727-167-41124
By:
- Beckman, Barbara;
- Maddux, Betty;
- Segaloff, Albert;
- Fisher, James W.
Publication type:
Article
A Soluble PC-1 Circulates in Human Plasma: Relationship with Insulin Resistance and Associated Abnormalities.
Published in:
Journal of Clinical Endocrinology & Metabolism, 1999, v. 84, n. 10, p. 3620, doi. 10.1210/jcem.84.10.6050
By:
- FRITTITTA, LUCIA;
- CAMASTRA, STEFANIA;
- BARATTA, ROBERTO;
- COSTANZO, BENEDETTA V.;
- D’ADAMO, MONICA;
- GRACI, SALVATORE;
- SPAMPINATO, DANIELA;
- MADDUX, BETTY A.;
- VIGNERI, RICCARDO;
- FERRANNINI, ELEUTERIO;
- TRISCHITTA, VINCENZO
Publication type:
Article
Biosynthesis and processing of the human insulin receptor.
Published in:
1986
By:
- Forsayeth, John;
- Maddux, Betty;
- Goldfine, Ira D.;
- Forsayeth, J;
- Maddux, B;
- Goldfine, I D
Publication type:
journal article
Tissue-specific antibodies against the fibroblast insulin receptor in a patient with lupus nephritis and hypoglycemia.
Published in:
1985
By:
- De Pirro, Roberto;
- Borboni, Patrizia;
- Lauro, Renato;
- Festa, Antonella;
- Testa, Ivano;
- De Martinis, Carlo;
- Maddux, Betty A.;
- Goldfine, Ira D.;
- De Pirro, R;
- Borboni, P;
- Lauro, R;
- Festa, A;
- Testa, I;
- De Martinis, C;
- Maddux, B A;
- Goldfine, I D
Publication type:
journal article
Role of PC-1 in The Etiology of Insulin Resistance.
Published in:
Annals of the New York Academy of Sciences, 1999, v. 892, n. 1, p. 204, doi. 10.1111/j.1749-6632.1999.tb07797.x
By:
- GOLDFINE, IRA D.;
- MADDUX, BETTY A.;
- YOUNGREN, JACK F.;
- TRISCHITTA, VINCENZO;
- FRITTITTA, LUCIA
Publication type:
Article
Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells.
Published in:
Journal of Cellular Biochemistry, 2008, v. 103, n. 2, p. 624, doi. 10.1002/jcb.21435
By:
- Zavodovskaya, Marianna;
- Campbell, Michael J.;
- Maddux, Betty A.;
- Shiry, Laura;
- Allan, Geoffrey;
- Hodges, Leslie;
- Kushner, Peter;
- Kerner, John A.;
- Youngren, Jack F.;
- Goldfine, Ira D.
Publication type:
Article
Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.
Published in:
Journal of Cellular Biochemistry, 2007, v. 102, n. 6, p. 1529, doi. 10.1002/jcb.21373
By:
- Meyer, Gary E.;
- Chesler, Louis;
- Liu, Dandan;
- Gable, Karissa;
- Maddux, Betty A.;
- Goldenberg, David D.;
- Youngren, Jack F.;
- Goldfine, Ira D.;
- Weiss, William A.;
- Matthay, Katherine K.;
- Rosenthal, Stephen M.
Publication type:
Article
Overexpression of membrane glycoprotein PC-1 can influence insulin action at a post-receptor site.
Published in:
Journal of Cellular Biochemistry, 1998, v. 68, n. 3, p. 366, doi. 10.1002/(SICI)1097-4644(19980301)68:3<366::AID-JCB7>3.0.CO;2-S
By:
- Kumakura, Shinobu;
- Maddux, Betty A.;
- Sung, Chin K.
Publication type:
Article
Nordihydroguaiaretic Acid (NDGA) Inhibits the IGF-1 and c-erbB2/HER2/neu Receptors and Suppresses Growth in Breast Cancer Cells.
Published in:
Breast Cancer Research & Treatment, 2005, v. 94, n. 1, p. 37, doi. 10.1007/s10549-005-6939-z
By:
- Jack Youngren;
- Karissa Gable;
- Cristina Penaranda;
- Betty Maddux;
- Marianna Zavodovskaya;
- Margaret Lobo;
- Michael Campbell;
- John Kerner;
- Ira Goldfine
Publication type:
Article
IGF-Binding Protein-1 Levels Are Related to Insulin-Mediated Glucose Disposal and Are a Potential Serum Marker of Insulin Resistance.
Published in:
2006
By:
- Maddux, Betty A.;
- Chan, Adelene;
- Mandarino, Lawrence J.;
- Goldfine, Ira D.
Publication type:
Case Study
Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells.
Published in:
Prostate, 2008, v. 68, n. 11, p. 1232, doi. 10.1002/pros.20789
By:
- Ryan, Charles J.;
- Zavodovskaya, Marianna;
- Youngren, Jack F.;
- Campbell, Michael;
- Diamond, Marc;
- Jones, Jeremy;
- Shiry, Laura;
- Allan, Geoffrey;
- Maddux, Betty A.;
- Goldfine, Ira D.
Publication type:
Article
Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance.
Published in:
2005
By:
- Dong, Hengjiang;
- Maddux, Betty A.;
- Altomonte, Jennifer;
- Meseck, Marcia;
- Accili, Domenico;
- Terkeltaub, Robert;
- Johnson, Kristen;
- Youngren, Jack F.;
- Goldfine, Ira D.
Publication type:
journal article
Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?
Published in:
2003
By:
- Evans, Joseph L;
- Goldfine, Ira D;
- Maddux, Betty A;
- Grodsky, Gerold M
Publication type:
journal article
Perspectives in Diabetes/ Are Oxidative Stress--Activated Signaling Pathways Mediators of Insulin Resistance and Β-Cell Dysfunction?
Published in:
Diabetes, 2003, v. 52, n. 1, p. 1, doi. 10.2337/diabetes.52.1.1
By:
- Evans, Joseph L.;
- Goldfine, Ira D.;
- Maddux, Betty A.;
- Grodsky, Gerold M.
Publication type:
Article
Small molecule insulin receptor activators potentiate insulin action in insulin-resistant cells.
Published in:
2001
By:
- Li, Ming;
- Youngren, Jack F.;
- Manchem, Vara Prasad;
- Kozlowski, Michael;
- Zhang, Bei B.;
- Maddux, Betty A.;
- Goldfine, Ira D.;
- Li, M;
- Youngren, J F;
- Manchem, V P;
- Kozlowski, M;
- Zhang, B B;
- Maddux, B A;
- Goldfine, I D
Publication type:
journal article
Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid.
Published in:
2001
By:
- Maddux, Betty A.;
- See, Wendy;
- Lawrence, Jr., John C.;
- Goldflne, Amy L.;
- Goldflne, Ira D.;
- Evans, Joseph L.;
- Maddux, B A;
- See, W;
- Lawrence, J C Jr;
- Goldfine, A L;
- Goldfine, I D;
- Evans, J L
Publication type:
journal article
Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit.
Published in:
2000
By:
- Maddux, Betty A.;
- Goldfine, Ira D.;
- Maddux, B A;
- Goldfine, I D
Publication type:
journal article
Skeletal Muscle Content of Membrane Glycoprotein PC-1 in Obesity.
Published in:
Diabetes, 1996, v. 45, n. 10, p. 1324, doi. 10.2337/diab.45.10.1324
By:
- Youngren, Jack;
- Maddux, Betty;
- Sasson, Shlomo;
- Sbraccia, Paolo;
- Tapscott, Edward;
- Swanson, Melvin;
- Dohm, G. Lynis;
- Goldfine, Ira
Publication type:
Article
Production of inhibitor of insulin-receptor tyrosine kinase in fibroblasts from patient with insulin resistance and NIDDM.
Published in:
1991
By:
- Sbraccia, Paolo;
- Goodman, Patricia A.;
- Maddux, Betty A.;
- Wong, K. Y.;
- Chen, Y.-D. I.;
- Reaven, Gerald M.;
- Goldfine, Ira D.;
- Sbraccia, P;
- Goodman, P A;
- Maddux, B A;
- Chen, Y D;
- Reaven, G M;
- Goldfine, I D
Publication type:
journal article
Mechanisms of insulin-induced insulin-receptor downregulation. Decrease of receptor biosynthesis and mRNA levels.
Published in:
1989
By:
- Okabayashi, Yoshinori;
- Maddux, Betty A.;
- McDonald, Alexander R.;
- Logsdon, Craig D.;
- Williams, John A.;
- Goldfine, Ira D.;
- Okabayashi, Y;
- Maddux, B A;
- McDonald, A R;
- Logsdon, C D;
- Williams, J A;
- Goldfine, I D
Publication type:
journal article
Sequence and analysis of promoter region of human insulin-receptor gene.
Published in:
1988
By:
- Mamula, Paul W.;
- Kwok-Ying Wong;
- Maddux, Betty A.;
- Mcdonald, Alexander R.;
- Goldfine, Ira D.;
- Mamula, P W;
- Wong, K Y;
- Maddux, B A;
- McDonald, A R;
- Goldfine, I D
Publication type:
journal article
Regulation of insulin-receptor mRNA levels by glucocorticoids.
Published in:
1987
By:
- McDonald, Alex R.;
- Maddux, Betty A.;
- Okabayashi, Y.;
- Wong, K. Y.;
- Hawley, D. M.;
- Logsdon, Craig D.;
- Goldfine, Ira D.;
- McDonald, A R;
- Maddux, B A;
- Logsdon, C D;
- Goldfine, I D
Publication type:
journal article
Chromium supplementation in non-obese non-diabetic subjects is associated with a decline in insulin sensitivity.
Published in:
BMC Endocrine Disorders, 2012, v. 12, n. 1, p. 31, doi. 10.1186/1472-6823-12-31
By:
- Masharani, Umesh;
- Gjerde, Christine;
- McCoy, Shelley;
- Maddux, Betty A.;
- Hessler, Danielle;
- Goldfine, Ira D.;
- Youngren, Jack F.
Publication type:
Article
Membrane glycoprotein in PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus.
Published in:
Nature, 1995, v. 373, n. 6513, p. 448, doi. 10.1038/373448a0
By:
- Maddux, Betty A.;
- Sbraccia, Paolo
Publication type:
Article
XOMA 052, an anti-IL-1β monoclonal antibody, prevents IL-1β-mediated insulin resistance in 3T3-L1 adipocytes.
Published in:
Obesity (19307381), 2013, v. 21, p. 306, doi. 10.1002/oby.20004
By:
- Handa, Masahisa;
- Vanegas, Sandra;
- Maddux, Betty A.;
- Mendoza, Nerissa;
- Zhu, Shirley;
- Goldfine, Ira D.;
- Mirza, Amer M.
Publication type:
Article
XOMA 052, an anti-IL-1β monoclonal antibody, prevents IL-1β-mediated insulin resistance in 3T3-L1 adipocytes.
Published in:
2013
By:
- Handa, Masahisa;
- Vanegas, Sandra;
- Maddux, Betty A;
- Mendoza, Nerissa;
- Zhu, Shirley;
- Goldfine, Ira D;
- Mirza, Amer M
Publication type:
journal article
XOMA 052, an anti-IL-1β monoclonal antibody, prevents IL-1β-mediated insulin resistance in 3T3-L1 adipocytes.
Published in:
Obesity (19307381), 2013, v. 21, n. 2, p. 306, doi. 10.1002/oby.20004
By:
- Handa, Masahisa;
- Vanegas, Sandra;
- Maddux, Betty A.;
- Mendoza, Nerissa;
- Zhu, Shirley;
- Goldfine, Ira D.;
- Mirza, Amer M.
Publication type:
Article
A Fully Human, Allosteric Monoclonal Antibody That Activates the Insulin Receptor and Improves Glycemic Control.
Published in:
Diabetes, 2012, v. 61, n. 5, p. 1263, doi. 10.2337/db11-1578
By:
- Bhaskar, Vinay;
- Goldfine, Ira D.;
- Bedinger, Daniel H.;
- Lau, Angela;
- Kuan, Hua F.;
- Gross, Lisa M.;
- Handa, Masahisa;
- Maddux, Betty A.;
- Watson, Susan R.;
- Zhu, Shirley;
- Narasimha, Ajay J.;
- Levy, Raphael;
- Webster, Lynn;
- Wijesuriya, Sujeewa D.;
- Naichi Liu;
- Xiaorong Wu;
- Chemla-Vogel, David;
- Tran, Catarina;
- Lee, Steve R.;
- Wong, Steve
Publication type:
Article

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