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- Title
Interstitial lung disease in infancy and early childhood: a clinicopathological primer.
- Authors
Laenger, Florian Peter; Schwerk, Nicolaus; Dingemann, Jens; Welte, Tobias; Auber, Bernd; Verleden, Stijn; Ackermann, Maximilian; Mentzer, Steven J.; Griese, Matthias; Jonigk, Danny
- Abstract
Children's interstitial lung disease (chILD) encompasses a wide and heterogeneous spectrum of diseases substantially different from that of adults. Established classification systems divide chILD into conditions more prevalent in infancy and other conditions occurring at any age. This categorisation is based on a multidisciplinary approach including clinical, radiological, genetic and histological findings. The diagnostic evaluation may include lung biopsies if other diagnostic approaches failed to identify a precise chILD entity, or if severe or refractory respiratory distress of unknown cause is present. As the majority of children will be evaluated and diagnosed outside of specialist centres, this review summarises relevant clinical, genetic and histological findings of chILD to provide assistance in clinical assessment and rational diagnostics.
- Subjects
INTERSTITIAL lung diseases; INFANT health; DISEASE prevalence; LUNG biopsy; RESPIRATORY distress syndrome
- Publication
European Respiratory Review, 2022, Vol 31, Issue 163, p1
- ISSN
0905-9180
- Publication type
Article
- DOI
10.1183/16000617.0251-2021