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- Title
Solvent-Free Synthesis of 4 H-Pyrido[1,2- a]pyrimidin-4-ones Catalyzed by BiCl<sub>3</sub>: A Green Route to a Privileged Backbone.
- Authors
Roslan, Irwan I.; Lim, Qiu‐Xuan; Han, Aijuan; Chuah, Gaik‐Khuan; Jaenicke, Stephan
- Abstract
An extensive array of 4 H-pyrido[1,2- a]pyrimidin-4-ones have been synthesized from commercially available 2-aminopyridines and β-oxo esters with excellent yields under solvent-free conditions. The reaction, catalyzed by cheap and nontoxic BiCl3, proceeds with short reaction times under mild conditions and normal atmosphere. Only water and alcohol are formed as co-products in this green reaction.
- Subjects
PYRIMIDINE synthesis; AMINOPYRIDINES; ESTERS; BISMUTH compounds; SUSTAINABLE chemistry
- Publication
European Journal of Organic Chemistry, 2015, Vol 2015, Issue 11, p2351
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201500227