We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Retro-Diels-Alder Protocol for the Synthesis of Pyrrolo[1,2- a]pyrimidine and Pyrimido[2,1- a]isoindole Enantiomers.
- Authors
Miklós, Ferenc; Tóth, Zita; Hänninen, Mikko M.; Sillanpää, Reijo; Forró, Enikő; Fülöp, Ferenc
- Abstract
A simple protocol was introduced to prepare several enantiomerically pure heterocycles by using (-)-(1 R,2 R,3 S,4 S)-3-aminonorbornene-2-carboxylic acid as a chiral auxiliary. The protocol is based on a domino ring-closure reaction, in which the relative configuration of the new asymmetric center is controlled by the stereochemistry of the amino acid, followed by a microwave-induced retro-Diels-Alder reaction.
- Subjects
PYRIMIDINE synthesis; ISOINDOLE; ENANTIOMERS; HETEROCYCLIC compounds; CARBOXYLIC acids; AMINO acids; RING formation (Chemistry)
- Publication
European Journal of Organic Chemistry, 2013, Vol 2013, Issue 22, p4887
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201300452