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- Title
Recipe for β-Sheets: Foldamers Containing Amyloidogenic Peptide Sequences.
- Authors
Spencer, Ryan; Chen, Kevin H.; Manuel, Gerald; Nowick, James S.
- Abstract
This paper describes a new class of macrocyclic peptides that fold to form β-sheet structures. These macrocyclic β-sheets consist of a peptide sequence strand linked through two δ-linked ornithine turn units to a peptide template strand containing a single N-methyl amino acid. The macrocycles were readily prepared from commercially available amino acids by solid-phase peptide synthesis followed by solution-phase cyclization. 1H NMR spectroscopic studies showed that macrocycles containing amyloidgenic pentapeptide sequences from amyloid β-peptide, tau protein, the B-chain of insulin, and human prion protein fold to form β-sheet structures.
- Subjects
PEPTIDE synthesis; AMINO acid sequence; AMINO acids; NUCLEAR magnetic resonance spectroscopy; TAU proteins; INSULIN
- Publication
European Journal of Organic Chemistry, 2013, Vol 2013, Issue 17, p3523
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201300221