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- Title
EFFECT OF 21-DAY ADMINISTRATION OF SPINACH ON OPERANT CONDITIONING BEHAVIOR-RELATED LEARNING AND MEMORY IN RATS.
- Authors
Thisayakorn, Krittiya; Limsiriwong, Pongsatorn; Nakakaew, Sawai; Khueynok, Vichein; Sriyam, Kanchana; Busabok, Sukanda; Banchonglikitkul, Chuleratana
- Abstract
The article presents information on a study conducted to determine whether Spinacia oleracea, or spinach (SP), could improve learning and memory impairment caused by scopolamine through operant conditioning procedure in rats. In the study, rats were trained for operant behavior in operant conditioning chambers for 4 months. Scopolamine, an acetylcholinesterase, was used to induce an impairment of learning and memory in rats. The rats were divided into four groups, and were orally given for 21 days water supplementation with SP and folic acid (FO) at different concentrations. The study found that SP supplements at 280 mg/kg/day was effective in reversing the learning and memory impairment induced by scopolamine.
- Subjects
PHARMACEUTICAL technology; SPINACH; MEMORY disorders; LEARNING disabilities; SCOPOLAMINE; OPERANT conditioning; ACETYLCHOLINESTERASE; FOLIC acid; SPINACIA
- Publication
Thai Journal of Pharmaceutical Sciences, 2012, Vol 36, p95
- ISSN
0125-4685
- Publication type
Article