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- Title
Understanding PK/PD.
- Authors
Roberts, Jason; Taccone, Fabio; Lipman, Jeffrey; Roberts, Jason A; Taccone, Fabio Silvio
- Abstract
The article discusses the studies of pharmacokinetics (PK) and pharmacodynamics (PD) that are central to pharmacodynamics. Topics include the definition of PK as the time-course of drug concentrations in the body and PD as the relationship between drug concentrations and pharmacological effects, the importance of PK/PD in optimising care in the intensive care unit (ICU), and the concepts in PK affecting antibiotic dosing.
- Subjects
PHARMACOKINETICS; PHARMACODYNAMICS; INTENSIVE care units; ANTIBIOTICS; DRUG dosage; CATASTROPHIC illness; DOSE-effect relationship in pharmacology
- Publication
Intensive Care Medicine, 2016, Vol 42, Issue 11, p1797
- ISSN
0342-4642
- Publication type
journal article
- DOI
10.1007/s00134-015-4032-6