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- Title
Association of Cytomegalovirus (CMV) DNAemia With Long-Term Mortality in a Randomized Trial of Preemptive Therapy and Antiviral Prophylaxis for Prevention of CMV Disease in High-Risk Donor Seropositive, Recipient Seronegative Liver Transplant Recipients.
- Authors
Kumar, Lakshin; Dasgupta, Sayan; Murray-Krezan, Cristina; Singh, Nina; Rakita, Robert M; Fisher, Cynthia E; Limaye, Ajit P
- Abstract
In a post-hoc analysis of the association of CMV DNAemia with long-term mortality in a randomized trial of CMV preemptive therapy vs. antiviral prophylaxis in D+R- liver transplant recipients, post-intervention CMV DNAemia was associated with increased mortality after adjusting for study arm.
- Subjects
CYTOMEGALOVIRUS disease prevention; MORTALITY risk factors; RISK assessment; PATIENTS; TRANSPLANTATION of organs, tissues, etc.; CRYOPRESERVATION of organs, tissues, etc.; VIRAL load; DATA analysis; RESEARCH funding; CYTOMEGALOVIRUS diseases; POLYMERASE chain reaction; DNA; MANN Whitney U Test; DESCRIPTIVE statistics; ANTIVIRAL agents; LONGITUDINAL method; KAPLAN-Meier estimator; LOG-rank test; VALGANCICLOVIR; STATISTICS; DATA analysis software; LIVER transplantation; TIME; PROPORTIONAL hazards models
- Publication
Clinical Infectious Diseases, 2024, Vol 78, Issue 3, p719
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciad643