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- Title
Clinical outcomes of retrograde intra-arterial chemotherapy concurrent with radiotherapy for elderly oral squamous cell carcinoma patients aged over 80 years old.
- Authors
Yuichiro Hayashi; Kenji Mitsudo; Kaname Sakuma; Masaki Iida; Toshinori Iwai; Hideyuki Nakashima; Yoshiyuki Okamoto; Toshiyuki Koizumi; Senri Oguri; Makoto Hirota; Mitomu Kioi; Izumi Koike; Masaharu Hata; Iwai Tohnai; Hayashi, Yuichiro; Mitsudo, Kenji; Sakuma, Kaname; Iida, Masaki; Iwai, Toshinori; Nakashima, Hideyuki
- Abstract
<bold>Background: </bold>The aim of this retrospective observational study was to evaluate toxicities, overall survival, and locoregional control in elderly oral squamous cell carcinoma patients who had undergone retrograde intra-arterial chemotherapy combined with radiotherapy.<bold>Methods: </bold>Thirty-one elderly patients over 80 years old with oral squamous cell carcinoma were enrolled in present study. The treatment schedule consisted of intra- arterial chemotherapy (docetaxel, total 60 mg/m2; cisplatin, total 150 mg/m2) and daily concurrent radiotherapy (total, 60 Gy) for 6 weeks.<bold>Results: </bold>The median patient age was 82.5 years old (range, 80-88 years). Of the 31 patients, six (19%) had stage II, 6 (19%) had stage III, 17 (55%) had stage IVA, and 2 (6%) had stage IVB. The median follow-up period for all patients was 37 months (range, 7-86 months). The 3-year overall survival and locoregional control rates were 78% and 81%, respectively. The major acute grade 3 adverse events were oral mucositis in 22 (71%) patients, neutropenia in 16 (52%), and dermatitis in 11 (35%). With respect to late toxicities, 1 patient (3%) developed grade 3 osteoradionecrosis of the jaw. No grade 4 or higher toxicities were observed during the treatment and follow-up periods.<bold>Conclusions: </bold>Retrograde intra-arterial chemotherapy combined with radiotherapy was effective in improving overall survival and locoregional control even for elderly patients.
- Subjects
CANCER chemotherapy; RADIOTHERAPY; SQUAMOUS cell carcinoma; MUCOSITIS; NEUTROPENIA; SKIN inflammation; ANTINEOPLASTIC agents; CISPLATIN; CANCER treatment; LONGITUDINAL method; MOUTH tumors; PROGNOSIS; SURVIVAL; RETROSPECTIVE studies; TUMOR treatment
- Publication
Radiation Oncology, 2017, Vol 12, p1
- ISSN
1748-717X
- Publication type
journal article
- DOI
10.1186/s13014-017-0847-3