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- Title
PET/CT versus triple endoscopy in initial workup of HPV+ oropharyngeal squamous cell carcinoma.
- Authors
Muller, Richard Grant; Weidenbecher, Mark; Ludlow, David
- Abstract
Background: Synchronous primary tumors (SPTs) are detected via triple endoscopy or positron emission tomography/computed tomography (PET/CT). Patients with human papillomavirus‐associated oropharyngeal squamous cell carcinoma (HPV+ OPSCC) lack risk factors for SPTs. Methods: We performed a single institution retrospective review of the efficacy of triple endoscopy and PET/CT in HPV+ OPSCC patients. Results: Sixty‐five HPV+ OPSCC patients underwent triple endoscopy and PET/CT. Patients were white (n = 48, 72.7%), male (n = 53, 81.5%), mean 58.7 ± 8.1 years old. SPT was detected in 1 (1.5%) patient via PET/CT. No SPTs were detected on triple endoscopy. PET/CT had 100% and 95.3% sensitivity and specificity, respectively. PET/CT positive predictive value (PPV) and negative predictive value (NPV) were 25.0% and 100%, respectively. Triple endoscopy specificity and NPV was 90.2% and 93.2%, respectively. Conclusions: PET/CT is superior to triple endoscopy in ruling out SPTs. With negative PET/CT, only direct laryngoscopy with biopsy may be necessary.
- Subjects
SQUAMOUS cell carcinoma; POSITRON emission tomography; ENDOSCOPY; COMPUTED tomography
- Publication
Head & Neck, 2022, Vol 44, Issue 5, p1164
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.27016