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- Title
The Biochemical Changes Following Gamma Irradiation of Packed Red Blood Cells: an Audit of a Blood Bank Performance.
- Authors
Masitah A. R.; Zefarina Z.; W. Suriana W. A. R.; M. Nazri H.; Lim S. H.; Rapiaah, M.; Ahmed, Suhair A.; W. Zaidah A.
- Abstract
Introduction: Transfusion-associated graft-versus-host disease (TA-GVHD) is an uncommon and nearly fatal complication of blood transfusion that can be prevented by blood products gamma irradiation. Unfortunately, gamma irradiation can cause biochemical changes in packed red blood cells (RBCs), which include elevation of potassium and lactate dehydrogenase (LDH), with a concomitant decrease in sodium levels. Objective: The aim of this study was to assess the difference of biochemical changes between gamma irradiated and non-irradiated packed RBCs as part of an audit program for the blood products in our blood bank. Materials and methods: Eight units of five-day-old saline-adenine-glucose-mannitol (SAGM)-preserved packed RBCs, were divided into two parts. All samples were stored at 2-6°C for up to 28 days. Sampling was done from both groups on day 0, 1, 7, 14, 21 and 28 post irradiation for potassium, sodium and LDH levels. Results: A progressive increase in the mean values of plasma potassium and LDH and a progressive decrease in mean value of plasma sodium were observed in both groups. Conclusion: The findings of this study indicated that irradiation increased storage lesion which could affect the red cell membrane function in regulating intracellular sodium and potassium levels. Therefore, potassium load may be clinically important in rapid, large-volume transfusions, such as neonatal exchange transfusion or intrauterine transfusion.
- Subjects
ERYTHROCYTES; AUDITING; BIOCHEMISTRY; BLOOD irradiation; GRAFT versus host disease; PHENOMENOLOGY
- Publication
International Medical Journal, 2016, Vol 23, Issue 4, p358
- ISSN
1341-2051
- Publication type
Article