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- Title
Eficacia y seguridad de antipsicóticos y antidepresivos en el tratamiento de la anorexia nerviosa: revisión sistemática.
- Authors
Carrillo Márquez, Melisa; Martínez Sánchez, Juliana; Salazar, Ana María; Vallejo Martínez, Carolina; Valderrama, Felipe; Rojas-Gualdrón, Diego Fernando
- Abstract
Introduction: The recommendations of the current guidelines are based on low quality evidence. Periodic updating is required, taking recent evidence into consideration. Objective: To synthesise the best available clinical evidence on the efficacy and safety of second-generation antidepressants and antipsychotics in patients with anorexia nervosa. Methods: Systematic review (CRD42020150577). We searched PubMed, SCOPUS, Ovid(Cochrane), EMBASE and LILACS for randomised clinical trials performed in patients with anorexia nervosa that evaluated the use of second-generation antipsychotics or oral antidepressants, at any dose and for any length of time, in outpatient and/or hospital treatment, taking weight (body mass index), psychopathological entities and safety as results. Results: Five studies were included, with four assessed as having a high risk of bias. The evidence indicates that patients receiving treatment with olanzapine or fluoxetine tend to stay in treatment programmes for longer. Olanzapine showed favourable results (one study) in terms of weight gain, but did not show the same results in psychopathology, where the evidence is contradictory. Conclusions: In accordance with previous reviews, our work allows us to conclude that there is contradictory information on the efficacy of psychotropic drugs in the treatment of anorexia nervosa. Futurework should focus on developing clinical trials of high methodological quality.
- Subjects
SECOND-generation antidepressants; ANOREXIA nervosa; PSYCHIATRIC drugs; BODY mass index; DRUG efficacy; WEIGHT gain
- Publication
Revista Colombiana de Psiquiatria, 2022, Vol 51, Issue 3, p227
- ISSN
0034-7450
- Publication type
Article
- DOI
10.1016/j.rcp.2020.11.009