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- Title
Rola receptorów adenozynowych w cukrzycy typu 2.
- Authors
Zieleniak, Andrzej; Georgiewa, Renata Dymitrowa; Wójcik, Marzena
- Abstract
In recent years an increasing incidence of type 2 diabetes mellitus (T2DM), associated with genetic, environmental, and ethnic factors, has led to serious social and economic consequences. Therefore, of particular interest is the development of new, effective, and safe antidiabetic drugs. In this context, several selective and high affinity synthetic agonists of adenosine receptor A1 (such as SDZ WAG-994, GR79236, ARA, CPA, CHA i CVT-3619), with the antilipolytic properties have been the subject of long-term intensive studies in vitro and in vivo. These compounds have been chosen and tested in various biological systems since it has been shown that stimulation of adenosine receptor A1 present in cell membranes of adipocytes resulted in lipolysis inhibition in these cells. In this review, characteristics adenosine receptors is demonstrated with a special emphasis on the role of adenosine receptor A1 in lipolysis. Moreover, a potential therapeutic utility of synthetic agonists of adenosine receptor A1 to treat insulin resistance and T2DM is outlined.
- Subjects
TYPE 2 diabetes treatment; ADENOSINES; PURINERGIC receptors; CHEMICAL agonists; HYPOGLYCEMIC agents; LIPOLYSIS; FAT cells; CELL membrane chemistry; INSULIN resistance; THERAPEUTICS
- Publication
Experimental & Clinical Diabetology / Diabetologia Doswiadczalna i Kliniczna, 2011, Vol 11, Issue 2, p69
- ISSN
1643-3165
- Publication type
Article