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- Title
Altered Distribution of Juxtaparanodal K<sub>v</sub>1.2 Subunits Mediates Peripheral Nerve Hyperexcitability in Type 2 Diabetes Mellitus.
- Authors
Zenker, Jennifer; Poirot, Olivier; De Preux Charles, Anne-Sophie; Arnaud, Estelle; Médard, Jean-Jacques; Lacroix, Catherine; Kuntzer, Thierry; Chrast, Roman
- Abstract
Peripheral nerve hyperexcitability (PNH) is one of the distal peripheral neuropathy phenotypes often present in patients affected by type 2 diabetes mellitus (T2DM). Through in vivo and ex vivo electrophysiological recordings in db/db mice, a model of T2DM, we observed that, in addition to reduced nerve conduction velocity, db/db mice also develop PNH. By using pharmacological inhibitors, we demonstrated that the PNH is mediated by the decreased activity of Kv1-channels. In agreement with these data, we observed that the diabetic condition led to a reduced presence of the Kv1.2-subunits in juxtaparanodal regions of peripheral nerves in db/db mice and in nerve biopsies from T2DM patients. Together, these observations indicate that the T2DM condition leads to potassium channel-mediated PNH, thus identifying them as a potential drug target to treat some of the DPN related symptoms.
- Subjects
PERIPHERAL nervous system physiology; TYPE 2 diabetes; NEUROPATHY; PERIPHERAL neuropathy; PHENOTYPES; ELECTROPHYSIOLOGY; LABORATORY mice
- Publication
Journal of Neuroscience, 2012, Vol 32, Issue 22, p7493
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.0719-12.2012