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- Title
Orthopoxvirus-Specific T-Cell Responses in Convalescent Mpox Patients.
- Authors
Traut, Caroline C; Jones, Joyce L; Sanders, Renata A; Clark, Laura R; Hamill, Matthew M; Stavrakis, Georgia; Sop, Joel; Beckey, Tyler P; Keller, Sara C; Gilliams, Elizabeth A; Cochran, Willa V; Laeyendecker, Oliver; Manabe, Yukari C; Mostafa, Heba H; Thomas, David L; Hansoti, Bhakti; Gebo, Kelly A; Blankson, Joel N
- Abstract
Orthopoxvirus-specific T-cell responses were analyzed in 10 patients who had recovered from Mpox including 7 people with human immunodeficiency virus (PWH). Eight participants had detectable virus-specific T-cell responses, including a PWH who was not on antiretroviral therapy and a PWH on immunosuppressive therapy. These 2 participants had robust polyfunctional CD4+ T-cell responses to peptides from the 121L vaccinia virus (VACV) protein. T-cells from 4 of 5 HLA-A2–positive participants targeted at least 1 previously described HLA-A2–restricted VACV epitope, including an epitope targeted in 2 participants. These results advance our understanding of immunity in convalescent Mpox patients.
- Subjects
MONKEYPOX; T cells; VACCINIA; HIV; IMMUNOSUPPRESSIVE agents
- Publication
Journal of Infectious Diseases, 2024, Vol 229, Issue 1, p54
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiad245