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- Title
Age-Dependent Differences in T-Cell Responses to Influenza A Virus.
- Authors
Prigge, Andrew D.; Ma, Ruihua; Coates, Bria M.; Singer, Benjamin D.; Ridge, Karen M.
- Abstract
Respiratory infections from influenza A virus (IAV) cause substantial morbidity and mortality in children relative to adults. T cells play a critical role in the host response to IAV by supporting the innate and humoral responses, mediating cytotoxic activity, and promoting recovery. There are age-dependent differences in the number, subsets, and localization of T cells, which impact the host response to pathogens. In this article, we first review how T cells recognize IAV and examine differences in the resting T-cell populations between juveniles and adults. Next, we describe how the juvenile CD4+, CD8+, and regulatory T-cell responses compare with those in adults and discuss the potential physiologic and clinical consequences of the differences. Finally, we explore the roles of two unconventional T-cell types in the juvenile response to influenza, natural-killer T cells and γδ T cells. A clear understanding of age-dependent differences in the T-cell response is essential to developing therapies to prevent or reverse the deleterious effects of IAV in children.
- Subjects
INFLUENZA A virus; T-cell receptor genes; MORTALITY; PATHOGENIC microorganisms; VIRAL pneumonia
- Publication
American Journal of Respiratory Cell & Molecular Biology, 2020, Vol 63, Issue 4, p415
- ISSN
1044-1549
- Publication type
Article
- DOI
10.1165/rcmb.2020-0169TR