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- Title
Chromosome 8 Polysomy Accounting for MYC Over-Expression in Angiosarcoma Arising as Somatic-Type Malignancy in Metastatic Teratoma. Case Report.
- Authors
Vargas, A. Cristina; Grimison, Peter; Joy, Christopher; Garrone, Bernadette; Bonar, Fiona; Ghahan, Raha Madadi; Davidson, Trent; Maclean, Fiona M.
- Abstract
MYC over-expression by immunohistochemistry (IHC) is utilised in routine pathology practice as a surrogate marker for MYC amplification, which plays a key oncogenic role in post-irradiation and chronic lymphedema-associated angiosarcoma. We present the case of a 32-year old male, who presented with high-grade angiosarcoma arising in a background of metastatic testicular teratoma. IHC for MYC showed strong nuclear expression in the angiosarcoma cells prompting the consideration of post-irradiation-induced angiosarcoma but our patient did not undergo radiotherapy. Fluorescence in-situ hybridization (FISH) excluded MYC amplification and instead showed Chromosome 8 polysomy, which accounted for the strong MYC IHC expression present, not previously described in the context of germ cell tumours. The occurrence of MYC over-expression due to polysomy illustrates a novel clinical scenario (angiosarcoma arising as somatic malignancy) where strong MYC IHC expression can be found in the absence of underlying amplification or prior radiotherapy exposure.
- Subjects
FLUORESCENCE in situ hybridization; ANGIOSARCOMA; TERATOMA; GENE amplification; CHROMOSOMES; BIOMARKERS; ALPHA fetoproteins
- Publication
International Journal of Surgical Pathology, 2022, Vol 30, Issue 4, p462
- ISSN
1066-8969
- Publication type
Article
- DOI
10.1177/10668969211067762